Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA

A Maran, MB Mathews - Virology, 1988 - Elsevier
In the absence of VA RNA,, protein synthesis in adenovirus-infected HeLa cells fails at late
times of infection because of defective initiation. The defect is due to the activation of a …

A mechanism for the control of protein synthesis by adenovirus VA RNAI

RP O'Malley, TM Mariano, J Siekierka, MB Mathews - Cell, 1986 - cell.com
Summary in the absence of VA RNA,, protein synthesis in adenovirus-infected HeLa cells
fails because of defective initiation. Earlier work showed that the defect results from …

Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus-infected cells

RP O'Malley, RF Duncan, JWB Hershey, MB Mathews - Virology, 1989 - Elsevier
A substantial body of data, largely derived from study of cell extracts, indicates that protein
synthesis in adenovirus-infected cells requires VA RNA 1 at late times of infection to prevent …

Control of translation in adenovirus-infected cells

MB Mathews - Enzyme, 1990 - karger.com
The initiation of protein synthesis in adenovirus-infected cells is regulated during the late
phase in two ways, which may be related. The overall translation rate is maintained by a …

Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of …

J Siekierka, TM Mariano, PA Reichel… - Proceedings of the …, 1985 - National Acad Sciences
The dl331 mutant of adenovirus serotype 5 fails to produce virus-associated (VA) RNAI, and
cells infected with this mutant do not synthesize proteins efficiently at late times in infection …

Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNAI.

KH Mellits, MB Mathews - The EMBO journal, 1988 - embopress.org
Adenovirus virus‐associated (VA) RNAI is required for efficient protein synthesis at late
times of adenoviral infection, and in some other situations where double‐stranded RNA …

Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.

RJ Schneider, B Safer, SM Munemitsu… - Proceedings of the …, 1985 - National Acad Sciences
The virus-associated VAI RNA of adenovirus is a small, RNA polymerase III-transcribed
species required for efficient translation of mRNAs late after infection. Deletion mutant dl331 …

Location of sequences on the adenovirus genome coding for the 5.5 S RNA

U Pettersson, L Philipson - Cell, 1975 - cell.com
The origin of a low molecular weight virus-associated RNA (VA-RNA) was mapped by
hybridization of VA-RNA to specific fragments of adenovirus type 2 DNA, obtained after …

The gene and messenger RNA for adenovirus polypeptide IX

U Pettersson, MB Mathews - Cell, 1977 - Elsevier
A small RNA species, distinct from the VA RNAs, has been identified in HeLa cells infected
with adenovirus type 2. The RNA, which has been purified using a novel screening …

Synthesis of viral ribonucleic acid during restricted adenovirus infection

RI Fox, SG Baum - Journal of virology, 1972 - Am Soc Microbiol
The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection
of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic …