A series of halogenated derivatives of natural flavonoids: baicalein and chrysin were
designed and investigated as possible ligands for the catalytic subunit of tumor‐associated …

CK2 is a ubiquitous protein kinase involved in many cell functions. During the last years it
became an interesting target in cancer research. A series of flavonoid compounds was …

The interaction of human CK2α with a series of tetrabromobenzotriazole (TBBt) and
tetrabromobenzimidazole (TBBz) analogs, in which one of the bromine atoms proximal to …

Protein kinase CK2 is a potential target for the discovery of anticancer drugs. Flavonoids are
reported to be effective CK2 inhibitors. Herein, based on structural trimming of flavonoids, a …

Objective To observe the effect of 7 flavonoids on recombinant human protein kinase CK 2
holoenzyme activity and investigate their structure-activity relationship. Methods …

Human protein kinase CK2 is an emerging target for neoplastic diseases. Potent lead
structures for human CK2 inhibitors are derived from dibenzofuranones. Two new …

Due to the emerging role of protein kinase CK2 as a molecule that participates not only in
the development of some cancers but also in viral infections and inflammatory failures, small …

Protein kinase CK2 is an emerging target for the therapeutic intervention in human diseases,
in particular in cancer. Inhibitors of this enzyme are at current in clinical trials indicating its …

Serine/threonine protein kinase CK2 controls vast variety of fundamental processes in cell
life; however, despite long period of study, its functional role is not completely determined …

Many polyphenolic compounds have been reported to inhibit protein kinases, with special
reference to CK2, a pleiotropic serine/threonine kinase, implicated in neoplasia …