Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …

Inflammatory bowel disease (IBD), typified by Crohn's disease and ulcerative colitis, is a
common disorder characterized by recurrent and serious inflammation of the gastrointestinal …

Considering that both innate and adaptive immune responses are involved in the
pathogenesis of Crohn's disease (CD), novel therapeutic options have significantly been …

Background Interleukin (IL)-12p70 and IL-23 are key T helper-1 (TH1) cytokines that drive
the inflammation seen in numerous models of intestinal inflammation. These molecules …

Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

Crohn's disease is an immune-mediated disease that is characterized by chronic intestinal
inflammation. Effector CD4+ T-lymphocytes are expanded in Crohn's disease-associated …

Biological agents have profoundly changed the therapeutical management of Crohn's
disease and ulcerative colitis, the major clinical subentities of inflammatory bowel disease …

ABSTRACT Introduction: Interleukin (IL)-23, a cytokine produced by antigen presenting
cells, targets both T cells and non-T cell types with the downstream effect of enhancing …

Abstract The interleukin-23 [IL-23] cytokine, derived predominantly from macrophages and
dendritic cells in response to microbial stimulation, has emerged as a critical promoter of …