The effects of environmental endocrine-disrupting chemicals (EDCs) are a great and
growing concern for human and animal development and life. The reproductive organs are …

The synthetic estrogen diethylstilbestrol (DES) is a potent perinatal endocrine disruptor. In
humans and experimental animals, exposure to DES during critical periods of reproductive …

Growing concerns over endocrine disrupting chemicals (EDCs) and their effects on human
fetal development and adult health have promoted research into the underlying molecular …

It is generally believed that estrogen receptor-dependent and-independent pathways are
involved in mediating the developmental effects of the synthetic estrogen, diethylstilbestrol …

Developmental exposure to a synthetic estrogen, diethylstilbestrol (DES), induces
carcinogenesis in human and laboratory animals. In mice, neonatal DES treatment induces …

Antenatal sex‐hormone exposure induces lesions in mouse reproductive organs, which are
similar to those in humans exposed in utero to a synthetic estrogen, diethylstilbestrol. The …

Neonatal diethylstilbestrol (DES) exposure elicits a wide range of abnormalities in the
female mouse genital tract. This animal model system is suitable for investigating the …

Data indicate that estrogen-dependent and-independent pathways are involved in the
teratogenic/carcinogenic syndrome that follows developmental exposure to 17β-estradiol or …

Estrogens regulate proliferation and differentiation of cells in target organs such as the
female reproductive tract. In mature mice, estrogens stimulate cell proliferation, whereas …

Endocrine disruptions induced by environmental toxicants have placed an immense burden
on society to properly diagnose, treat and attempt to alleviate symptoms and disease …