Topical application of doxycycline inhibits Th2 cell development mediated by Langerhans cells and exerts a therapeutic effect on atopic dermatitis

K Matsui, Y Nojima, Y Kajiwara… - … of Pharmacy & …, 2020 - journals.library.ualberta.ca
Background: Langerhans cells (LCs) polarize the immune milieu towards a T helper type
(Th) 1 or Th2 immune response. We investigated the effects of selected tetracyclines on Th …

[HTML][HTML] Betamethasone, but not tacrolimus, suppresses the development of Th2 cells mediated by Langerhans cell-like dendritic cells

K Matsui, S Tamai, R Ikeda - Biological and Pharmaceutical Bulletin, 2016 - jstage.jst.go.jp
It is well known that Langerhans cells (LCs) work as the primary orchestrators in the
polarization of the immune milieu towards a T helper type 1 (Th1) or T helper type 2 (Th2) …

Norfloxacin, a fluoroquinolone antibiotic, inhibits Langerhans cell-mediated Th1 and Th2 cell development

K Matsui, A Kashima, A Motegi - Journal of Pharmacy & …, 2019 - journals.library.ualberta.ca
Background: It is widely acknowledged that Langerhans cells (LCs) play a primary role in
the polarization of T helper type 1 (Th1) or T helper type 2 (Th2) immune responses. Our aim …

Effects of macrolide antibiotics on Th1 cell and Th2 cell development mediated by Langerhans cells

K Matsui, S Tamai, R Ikeda - Journal of Pharmacy & …, 2016 - journals.library.ualberta.ca
Background: It is well known that Langerhans cells (LCs) work as the primary orchestrators
in the polarization of the immune milieu towards a T helper type 1 (Th1) or a Th2 immune …

Effects of anti-allergy drugs on Th1 cell and Th2 cell development mediated by Langerhans cells

K Matsui, X Shi, S Komori… - Journal of Pharmacy & …, 2020 - journals.library.ualberta.ca
Background: It is well known that Langerhans cells (LCs) work as the primary orchestrators
in polarization towards T helper type 1 (Th1) or T helper type 2 (Th2) immune responses. In …

Topical application of josamycin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice

K Matsui, K Tachioka… - Journal of Pharmacy …, 2017 - journals.library.ualberta.ca
Background: Patients with atopic dermatitis (AD) have superficial skin colonization by
Staphylococcus aureus and an increased number of T helper type 2 (Th2) cells in their …

[HTML][HTML] Combination Therapy with Betamethasone and Josamycin Demonstrates Superior Therapeutic Efficacy in an NC/Nga Mouse Model of Atopic Dermatitis

K Matsui, M Muranaka, T Yamaguchi… - Biological and …, 2023 - jstage.jst.go.jp
We have previously demonstrated the excellent bactericidal activity of josamycin against
Staphylococcus aureus isolated from patients with atopic dermatitis (AD), with therapeutic …

A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis

C Xiao, Z Zhu, C Zhang, J Gao, Y Luo, H Fang… - Frontiers in …, 2022 - frontiersin.org
Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic
dermatitis (AD). However, the specific role of different subsets of DCs has not been well …

Topical tetracycline improves MC903-induced atopic dermatitis in mice through inhibition of inflammatory cytokines and thymic stromal lymphopoietin expression

XJ Liu, ZL Mu, Y Zhao, JZ Zhang - Chinese medical journal, 2016 - mednexus.org
Background: Tetracycline (TET) has been found to have both antibiotic and anti-
inflammatory properties. The anti-inflammatory effect of topical TET on atopic dermatitis (AD) …

Tacrolimus and TGF-β act synergistically on the generation of Langerhans cells

B Kwiek, WM Peng, JP Allam, A Langner… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: The proportion of dendritic cell subpopulations in the skin is important for
the severity of atopic dermatitis because topical treatment with tacrolimus leads to rapid …