The neuropathic diabetic foot ulcer microbiome is associated with clinical factors

SE Gardner, SL Hillis, K Heilmann, JA Segre… - Diabetes, 2013 - Am Diabetes Assoc
Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes.
Microbial burden, or “bioburden,” is believed to underlie delayed healing, although little is …

[PDF][PDF] Strain-and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy

LR Kalan, JS Meisel, MA Loesche, J Horwinski… - Cell host & …, 2019 - cell.com
Chronic wounds are a major complication of diabetes associated with high morbidity and
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …

[HTML][HTML] Next generation DNA sequencing of tissues from infected diabetic foot ulcers

M Malone, K Johani, SO Jensen, IB Gosbell… - …, 2017 - thelancet.com
We used next generation DNA sequencing to profile the microbiome of infected Diabetic
Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment …

[HTML][HTML] Bacterial diversity of diabetic foot ulcers: current status and future prospectives

F Sadeghpour Heravi, M Zakrzewski, K Vickery… - Journal of clinical …, 2019 - mdpi.com
Diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) are associated with reduced
patient quality of life, lower-extremity amputation, hospitalization, and high morbidity and …

[HTML][HTML] One step closer to understanding the role of bacteria in diabetic foot ulcers: characterising the microbiome of ulcers

K Smith, A Collier, EM Townsend, LE O'Donnell… - BMC microbiology, 2016 - Springer
Background The aim of this study was to characterise the microbiome of new and recurrent
diabetic foot ulcers using 16S amplicon sequencing (16S AS), allowing the identification of a …

New molecular techniques to study the skin microbiota of diabetic foot ulcers

JP Lavigne, A Sotto, C Dunyach-Remy… - Advances in wound …, 2015 - liebertpub.com
Significance: Diabetic foot ulcers (DFU) are a major and growing public health problem.
They pose difficulties in clinical practice in both diagnosis and management. Bacterial …

[HTML][HTML] Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)

SE Dowd, RD Wolcott, Y Sun, T McKeehan, E Smith… - PloS one, 2008 - journals.plos.org
Background Diabetic extremity ulcers are associated with chronic infections. Such ulcer
infections are too often followed by amputation because there is little or no understanding of …

The role of the microbiome in nonhealing diabetic wounds

LR Kalan, MB Brennan - Annals of the New York Academy of …, 2019 - Wiley Online Library
Wound healing is a highly coordinated and complex process, and there can be devastating
consequences if it is interrupted. It is believed that, in combination with host factors …

Wound bioburden and infection-related complications in diabetic foot ulcers

SE Gardner, RA Frantz - Biological research for nursing, 2008 - journals.sagepub.com
The identification and diagnosis of diabetic foot ulcer (DFU) infections remains a complex
problem. Because inflammatory responses to microbial invasion may be diminished in …

[HTML][HTML] Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies

SG Pereira, J Moura, E Carvalho… - Frontiers in …, 2017 - frontiersin.org
World Health Organization considered diabetes as one of the 20th century epidemics,
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …