Oral tolerance, an important feature of the mucosal immune system, appears to protect
against immune-mediated disease by blunting production of systemic IgG and IgM antibody …

To test the hypothesis that IgA nephropathy can result from a mucosal immune response,
mice were orally immunized with one of three protein antigens for 14 wk. Such mice …

We sought to determine if codeposits of IgG and IgM and glomerular complement, observed
in most cases of human IgA nephropathy, might be important for inducing hematuria. All …

This report reviews the immunophysiology of the mucosal immune system, the principal
antibody of which is a special form of IgA, termed secretory IgA. This IgA is produced locally …

An animal model for IgA immune complex nephritis was developed. IgA immune complexes
formed in vitro with an IgA anti-dinitrophenyl (DNP) derived from MOPC-315 plasmacytoma …

SUMMARY An acute model Tor IgA-mediated glomerular inflammation in rats was induced
by the in situ deposition of IgA directly into the glomerular mesangium. F (ab') 2 anti-Thyl …

Antibody affinity affects the handling and behaviour of immune complexes, and experimental
studies have shown that animals which produce predominantly low‐affinity antibody are …

The systemic immune response to a booster dose of attenuated polio vaccine has been
studied in a group of patients with IgA nephropathy, their parents and healthy unrelated …

Molecular size and charge distribution of IgA of sera and glomerular eluates were
investigated in ddY mice, spontaneously developing mesangial proliferative …

Experimental pathology offers an approach to the study of disease that complements clinical
observations and studies of human material in vitro. The power and utility of animal models …