During the past decade, the genetics of type 1 (insulin-dependent) diabetes mellitus (IDDM)
has been studied extensively and the disorder has become a paradigm for genetically …

To identify new loci predisposing to insulin-dependent diabetes mellitus (IDDM), we have
investigated 250 families with more than one diabetic child. Affected sibling pair linkage …

Genetic analysis of a mouse model of major histocompatability complex (MHC)-associated
autoimmune type 1 (insulin-dependent) diabetes mellitus (IDDM) has shown that the …

Genetic and environmental factors interact to cause insulin dependent diabetes mellitus
(IDDM), also referred to as type 1 diabetes. In the mid-1970's, association and affected sib …

Non–insulin dependent diabetes mellitus (NIDDM) affects more than 100 million people
worldwide1, 2 and is associated with severe metabolic defects, including peripheral insulin …

Abstract Type 1 diabetes (T1D; or insulin-dependent diabetes mellitus, IDDM) is an
autoimmune disease with both genetic and environmental components. In addition to the …

The IDDM2 locus encoding susceptibility to type 1 diabetes was mapped previously to a 4.1–
kb region spanning the insulin gene and a minisatellite or variable number of tandem …

INSULIN-dependent (type I) diabetes mellitus (IDDM) follows an autoimmune destruction of
the insulin-producing β-cells of the pancreas1, 2. Family and population studies indicate that …

Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …

We have searched the human genome for genes that predispose to type 1 (insulin-
dependent) diabetes mellitus using semi-automated fluorescence-based technology and …