Etiopathogenesis of inflammatory bowel disease: today and tomorrow

HSP de Souza - Current opinion in gastroenterology, 2017 - journals.lww.com
The continuing identification of several epigenetic, transcriptomic, proteomic, and
metabolomic alterations in patients with IBD reflects the complex nature of the disease and …

The genetic architecture of inflammatory bowel disease: past, present and future

I Cleynen, S Vermeire - Current opinion in gastroenterology, 2015 - journals.lww.com
Genetic, transcriptomic and epigenetic studies have offered exciting clues about IBD
pathogenesis but are unlikely to provide all answers. To fully grasp the function of disease …

Advances in the molecular dissection of inflammatory bowel disease

KA Siminovitch - Seminars in Immunology, 2006 - Elsevier
Recent advances in the field of inflammatory bowel disease (IBD) genetics have enabled the
definition and refinement of multiple IBD susceptibility loci and the identification of gene …

[HTML][HTML] Inflammatory bowel disease: genetics, epigenetics, and pathogenesis

I Loddo, C Romano - Frontiers in immunology, 2015 - frontiersin.org
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …

Microbial genes and pathways in inflammatory bowel disease

M Schirmer, A Garner, H Vlamakis… - Nature Reviews …, 2019 - nature.com
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …

Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine

P Goyette, C Labbé, TT Trinh, RJ Xavier… - Annals of …, 2007 - Taylor & Francis
Crohn's disease (CD) and ulcerative colitis (UC), also known as inflammatory bowel
diseases (IBD), are characterized by chronic inflammation of the gastrointestinal tract. IBD is …

Inflammatory bowel disease pathogenesis: where are we?

C Fiocchi - Journal of gastroenterology and hepatology, 2015 - Wiley Online Library
Inflammatory bowel disease (IBD) is presently one of the most investigated human
disorders. Expansion of knowledge of its pathophysiology has helped in developing novel …

[HTML][HTML] Delineating inflammatory bowel disease through transcriptomic studies: current review of progress and evidence

SN Chan, EN Den Low, RAR Ali, NM Mokhtar - Intestinal research, 2018 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), which comprises of Crohn's disease and ulcerative
colitis, is an idiopathic relapsing and remitting disease in which the interplay of different …

[HTML][HTML] Inflammatory bowel disease: updates on molecular targets for biologics

KH Katsanos, KA Papadakis - Gut and Liver, 2017 - ncbi.nlm.nih.gov
Therapy for inflammatory bowel disease (IBD) has changed, with several new agents being
evaluated. The era of anti-tumor necrosis factor (anti-TNF) antibody therapy saw remarkable …

Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy

A Schirbel, C Fiocchi - Journal of digestive diseases, 2010 - Wiley Online Library
Modern studies of inflammatory bowel disease (IBD) pathogenesis have been pursued for
about four decades, a period of time where the pace of progress has been steadily …