Rheumatoid Arthritis (RA) is the most common chronic inflammatory autoimmune disease
involving joints. Among several pathogenic mechanisms, the impairment of homeostatic …

Rheumatoid Arthritis (RA) is the most common chronic inflammatory autoimmune disease
involving joints. Among several pathogenic mechanisms, the impairment of homeostatic …

Introduction The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are
important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these …

Protein S (ProS) and growth-arrest-specific protein 6 (Gas6) are both ligands for TAM
receptors, a family of receptor tyrosin kinases consisting of Axl, Mertk and Tyro3. Activation …

Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage
degeneration, synovitis, and bone sclerosis, resulting in swelling, stiffness, and joint pain …

Background: Growth arrest specific 6 (GAS 6) is the ligand for the TAM family of receptors.
The TAM acronym is for the three members of this family: Tyro3, Axl, and Mer. Deficiencies in …

Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease associated with
impaired immune system regulation. The exact mechanisms of SLE development remain to …

Objective Hyperactivation of innate immunity by Toll‐like receptors (TLRs) can contribute to
the development of autoinflammatory or autoimmune diseases. This study evaluated the …

TAM (TYRO3, AXL and MERTK) protein tyrosine kinase membrane receptors and their
vitamin K-dependent ligands GAS6 and Protein S (PROS) are well-known players in tumor …

Objective. To investigate the role of TAM receptors in rheumatoid arthritis (RA) by
determining synovial tissue TAM receptor expression, synovial fluid levels of soluble TAM …