We raised specific antisera against recombinant VAR2CSA domains produced in
Escherichia coli and in insect cells. All were reactive in enzyme-linked immunosorbent …

The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …

In areas of endemicity pregnancy-associated malaria is an important cause of maternal
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …

During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …

Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …

Background Pregnancy associated malaria is a severe clinical syndrome associated with
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …

Sequestration of Plasmodium falciparum-infected erythrocytes in the placenta is implicated
in pathological outcomes of pregnancy-associated malaria (PAM). P. falciparum isolates that …

Abstract Background In pregnancy, Plasmodium falciparum parasites express the surface
antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A …

The variant surface antigen VAR2CSA is a pregnancy malaria vaccine candidate, but its size
and polymorphism are obstacles to development. We expressed 3D7-type VAR2CSA …

Background. Plasmodium falciparum-infected erythrocytes adhere to chondroitin sulfate A
(CSA) to sequester in the human placenta, and pregnancy malaria (PM) is associated with …