Female infertility syndromes are among the most prevalent chronic health disorders in
women, but their genetic basis remains unknown because of uncertainty regarding the …

Mammalian folliculogenesis and oocyte physiology are complex and not fully understood.
However, major advances over the past 15 years in our ability to create and study in vivo …

The oocyte is a key regulator of ovarian folliculogenesis and early embryonic development.
However, the composition of the oocyte transcriptome and identities and functions of key …

Background Genes specifically expressed in the oocyte play key roles in oogenesis, ovarian
folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify …

The identification of genes and deduced pathways from the mature human oocyte can help
us better understand oogenesis, folliculogenesis, fertilization, and embryonic development …

Cross-phylum and cross-species comparative transcriptomic analyses provide an
evolutionary perspective on how specific tissues use genomic information. A significant …

An oocyte's journey is highly distinct from the vast majority of cells in the body. As one of the
largest and rarest cells, oocytes express unique genes required for the genesis of healthy …

Although cell-autonomous genetic programs pursued by germ and somatic cells are of
critical import, intimate interplays between the two cell types are also essential for normal …

The pool of primordial follicles in humans is laid down during embryonic development and
follicles can remain dormant for prolonged intervals, often decades, until individual follicles …

Ovarian follicle development is a complex process that begins with the establishment of
what is thought to be a finite pool of primordial follicles and culminates in either the atretic …