A prospective phase I–II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor …
FG Herrera, P Chan, C Doll, M Milosevic, A Oza… - International Journal of …, 2007 - Elsevier
Purpose: To evaluate the toxicity and effectiveness of celecoxib in combination with
definitive chemoradiotherapy (CRT) in women with locally advanced cervical cancer …
definitive chemoradiotherapy (CRT) in women with locally advanced cervical cancer …
A Phase II study of acute toxicity for Celebrex™(celecoxib) and chemoradiation in patients with locally advanced cervical cancer: primary endpoint analysis of RTOG …
DK Gaffney, K Winter, AP Dicker, B Miller… - International Journal of …, 2007 - Elsevier
Purpose: To determine treatment-related acute toxicity rates in patients with locally
advanced cervical cancer treated by oral celecoxib, iv cisplatin and 5-FU, and concurrent …
advanced cervical cancer treated by oral celecoxib, iv cisplatin and 5-FU, and concurrent …
COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: a quantitative immunohistochemical …
CM Doll, K Winter, DK Gaffney, JK Ryu… - International Journal of …, 2013 - ijgc.bmj.com
Purpose This study aimed to measure expression of cyclooxygenase-2 (COX-2) and CD34
in pretreatment tumor biopsies from patients on the RTOG C0128 phase II study, and to …
in pretreatment tumor biopsies from patients on the RTOG C0128 phase II study, and to …
Efficacy and patterns of failure for locally advanced cancer of the cervix treated with celebrex (celecoxib) and chemoradiotherapy in RTOG 0128
DK Gaffney, K Winter, AP Dicker, B Miller… - International Journal of …, 2007 - Elsevier
PURPOSE: To determine the efficacy and patterns of initial failure for oral celecoxib,
intravenous cisplatin, and 5-fluorouracil and concurrent pelvic radiotherapy in patients with …
intravenous cisplatin, and 5-fluorouracil and concurrent pelvic radiotherapy in patients with …
Celecoxib modulates the expression of cyclooxygenase-2, ki67, apoptosis-related marker, and microvessel density in human cervical cancer: a pilot study
G Ferrandina, FO Ranelletti, F Legge, L Lauriola… - Clinical cancer …, 2003 - AACR
Purpose: We investigated whether a short treatment with the cyclooxygenase-2 (COX-2)
inhibitor celecoxib could modulate Ki67 antigen and the caspase cleavage product of …
inhibitor celecoxib could modulate Ki67 antigen and the caspase cleavage product of …
A stratified randomized double-blind phase II trial of celecoxib for treating patients with cervical intraepithelial neoplasia: the potential predictive value of VEGF serum …
JS Rader, MW Sill, JH Beumer, HA Lankes… - Gynecologic …, 2017 - Elsevier
Purpose To examine the effect of celecoxib on cervical intraepithelial neoplasia 3 (CIN 3).
This is a NRG Oncology/Gynecologic Oncology Group study with translational biomarkers …
This is a NRG Oncology/Gynecologic Oncology Group study with translational biomarkers …
Celecoxib radiosensitizes the human cervical cancer HeLa cell line via a mechanism dependent on reduced cyclo-oxygenase-2 and vascular endothelial growth …
AH Wang, XY Tian, JJ Yu, JQ Mi… - Journal of …, 2012 - journals.sagepub.com
OBJECTIVE: The effects of celecoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor, on
HeLa cervical cancer cell growth and radiosensitivity were investigated. METHODS …
HeLa cervical cancer cell growth and radiosensitivity were investigated. METHODS …
Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy
DK Gaffney, J Holden, M Davis, K Zempolich… - International Journal of …, 2001 - Elsevier
Purpose: The purpose of this study was to examine the relationship between overall survival
and prognostic factors in carcinoma of the cervix treated with radiation therapy. A …
and prognostic factors in carcinoma of the cervix treated with radiation therapy. A …
A randomized double-blind placebo-controlled phase II trial of the cyclooxygenase-2 inhibitor Celecoxib in the treatment of cervical dysplasia
JH Farley, V Truong, E Goo, C Uyehara, C Belnap… - Gynecologic …, 2006 - Elsevier
OBJECTIVES.: The objective of the study was to evaluate the efficacy of daily Celecoxib in
the regression of moderate and severe cervical dysplasia, when compared to placebo …
the regression of moderate and severe cervical dysplasia, when compared to placebo …
Novel chemotherapy approaches in chemoradiation protocols
L González-Cortijo, N Carballo, A Gonzalez-Martin… - Gynecologic …, 2008 - Elsevier
Locally advanced cervical carcinoma had been treated with radiation therapy until 1999,
when five different large clinical trials showed an overall survival benefit when …
when five different large clinical trials showed an overall survival benefit when …