Cyclic GMP metabolism has been investigated in the retinas of mice that are heterozygous
for a 'photoreceptor dystrophy'gene and have a lowered concentration of cGMP in their …

The effect of light on the content of cyclic GMP in degenerative retinae of Royal College of
Surgeons (RCS) rats and rd mice was compared with that in control retinae during postnatal …

We have examined cyclic GMP concentrations, guanylate cyclase activities, and cyclic GMP
phosphodiesterase (PDE) activities in developing retinas of congenic mice with different …

Cyclic GMP and its enzyme of metabolism, Phosphodiesterase,(PDE) appear to be involved
in the normal processes of vision. An abnormality in the development of cyclic GMP PDE in …

Cyclic GMP accumulates in visual cells of rd (retinal degeneration) mice before the onset of
morphological pathology. Observations are presented which support the hypothesis that …

The activities of guanylate cyclase, guanosine 3', 5'-monophosphate (cyclic GMP)
phosphodiesterase and 5'-nucleotidase were measured during postnatal development in …

In the retina of the mouse heterozygous for retinal degeneration (+ rd) cGMP levels are
reported to be considerably reduced from normal. The sensitivity and timing of the a-and b …

Extremely high activities of guanylate cyclase [l] and guanosine cyclic 3', 5'monophosphate
(cGMP) phosphodiesterase [2], the enzymes of cGMP formation and degradation have been …

The kinetic characteristics and enzyme activities of cyclic nucleotide phosphodiesterase
(PDE), using cyclic-AMP (cyclic-AMP-PDE) or cyclic-GMP (cyclic-GMP-PDE) as substrate …

Levels of cyclic AMP and cyclic GMP were measured in light and dark adapted retinas from
normal mice (++/++) and from mice heterozygous for the photoreceptor dystrophy gene …