The extracellular Ca 2+-sensing receptor (CaR) is an unusual member of the diverse
superfamily of seven-transmembrane domain G-protein-coupled receptors. Originally …

The calcium-sensing receptor (CaR) belongs to the G protein-coupled receptor superfamily,
with a characteristic structure consisting of seven transmembrane helices, an intracellular C …

Calcium (Ca2+) has long been recognized as a physiologically indispensable ion owing to
its numerous intra-and extracellular roles. More recently, it has become apparent that …

The cloning of a G protein-coupled, extracellular Ca 2+(Ca o 2+)-sensing receptor (CaR)
has afforded a molecular basis for a number of the known effects of Ca o 2+ on tissues …

Extracellular Ca2+ concentration [Ca2+] o is vital for a number of processes varying from
blood clotting to regulation membrane permeability and excitability. For this reason [Ca2+] o …

In mammals Ca2+ concentration in the extracellular fluids ([Ca2+] o) is essential for a
number of vital processes varying from bone mineralization to blood coagulation, regulation …

The extracellular calcium (Ca 2+ o)-sensing receptor (CaR) is a G protein-coupled receptor
that plays important roles in calcium homeostasis. In this study, we employed epitope …

Publisher Summary Ca 2+ serves as a versatile extracellular first messenger, in many
instances acting via the Ca 2+-sensing receptor (CaR) that controls numerous physiological …

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled
receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It …

Critical to cell fate in many cell types is the ability to sense and respond to acute changes in
free ionized extracellular calcium concentration ([Ca2+] o). Such tight control is mediated by …