Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …

A brief comparison of the pathophysiology of inflammatory ve... : Current Opinion in
Anesthesiology A brief comparison of the pathophysiology of inflammatory versus neuropathic …

Neuropathic pain often fails to respond to conventional pain management procedures. here
we review the aetiology of neuropathic pain as would result from peripheral neuropathy or …

Neuropathic pain remains one of the most challenging of all neurological diseases and
presents a large unmet need for improved therapies. Many mechanistic details are still …

Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Neuropathic pain is defined aspain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …

Neuroinflammation is a proinflammatory cytokine-mediated process that can be provoked by
systemic tissue injury but it is most often associated with direct injury to the nervous system …

The transition from acute to chronic pain appears to occur in discrete pathophysiological and
histopathological steps. Stimuli initiating a nociceptive response vary, but receptors and …