Phenotypic and functional status of intrahepatic T cells in chronic hepatitis C

J Wang, TH Holmes, LL Guevara… - The Journal of …, 2006 - academic.oup.com
Polychromatic flow-cytometric assays were used to analyze paired intrahepatic and
peripheral lymphocyte samples from 37 patients with chronic hepatitis C. Compared with …

Naive and memory T cell infiltrates in chronic hepatitis C: phenotypic changes with interferon treatment

K Imada, Y Fukuda, Y Koyama, I Nakano… - Clinical & …, 1997 - Wiley Online Library
The phenotypes of infiltrating lymphocytes in liver with chronic hepatitis C, including
changes associated with interferon (IFN) treatment, were characterized. Specimens …

Increased frequency of IFN‐γ‐producing peripheral CD8+ T cells with memory‐phenotype in patients with chronic hepatitis C

M Murata, S Nabeshima, N Maeda… - Journal of Medical …, 2002 - Wiley Online Library
To identify the capacity for cytokine production and the phenotypic characteristics of
peripheral CD8+ T cells in patients with chronic hepatitis C, 31 patients with chronic hepatitis …

[PDF][PDF] Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C

V Leroy, I Vigan, JF Mosnier, T Dufeu‐Duchesne… - …, 2003 - Wiley Online Library
The pathogenesis of liver cell injury during chronic hepatitis C (CHC) is poorly understood.
The cellular immune response is thought to play a key role in both inhibition of viral …

Visual demonstration of hepatitis C virus-specific memory CD8+ T-cell expansion in patients with acute hepatitis C

Y Sobao, H Tomiyama, S Nakamura, H Sekihara… - Hepatology, 2001 - Elsevier
Hepatitis C virus (HCV)-specific CD8+ T cells in peripheral blood mononuclear cells
(PBMCs) from patients infected with HCV were quantitatively analyzed by flow cytometry …

Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections

A Bertoletti, MM D'Elios, C Boni, M De Carli… - Gastroenterology, 1997 - Elsevier
BACKGROUND & AIMS: The cytokine pattern secreted by T cells at the site of viral
replication may influence the final outcome of hepatitis B virus (HBV) and hepatitis C virus …

Liver‐infiltrating and circulating CD4+ T cells in chronic hepatitis C: immunodominant epitopes, HLA‐restriction and functional significance

HF Löhr, JF Schlaak, S Kollmannsperger, HP Dienes… - Liver, 1996 - Wiley Online Library
The aim was to assess the specificity and functional significance of liver‐infiltrating and
peripheral blood T cells in chronic hepatitis C. Peripheral blood mononuclear cells hepatitis …

Antigen-independent activation of resting T-cells in the liver of patients with chronic hepatitis.

S Abrignani - Developments in biological standardization, 1998 - europepmc.org
Since the adult liver is an organ without constitutive lymphoid components, any intra-hepatic
T cell found in chronic viral hepatitis should have compartmentalised to the liver after …

Divergent contributions of regulatory T cells to the pathogenesis of chronic hepatitis C

AA Self, PT Losikoff, SH Gregory - Human Vaccines & …, 2013 - Taylor & Francis
Hepatitis C virus, a small single-stranded RNA virus, is a major cause of chronic liver
disease. Resolution of primary hepatitis C virus infections depends upon the vigorous …

Hepatic and peripheral T-lymphocyte patterns in patients with chronic hepatitis C infection: what correlation with histological activity?

A Perrella, O Perrella, C Sbreglia, P Conca… - International Journal …, 2001 - europepmc.org
The immunopathological processes involved in hepatic damage during chronic hepatitis C
infection are not fully understood. Several works suggest the role of T helper 1 (Th1) immune …