Amorphous solid dispersions (ASDs) are often used for formulating poorly water-soluble
active pharmaceutical ingredients (APIs). In an ASD, the amorphous API is embedded in a …

The molecular integration of poorly water soluble active pharmaceutical ingredients (APIs) in
a suitable polymeric matrix is a possible approach to enhance the dissolution behavior and …

The bioavailability of poorly-water-soluble active pharmaceutical ingredients (APIs) can be
significantly improved by so-called amorphous solid dispersions (ASDs). However, the long …

The preparation of amorphous solid dispersions (ASDs) is a well-established strategy for
formulating active pharmaceutical ingredients by embedding them in excipients, usually …

Understanding and prevention of unwanted changes of a pharmaceutical formulation during
the production process is part of the critical requirements for the successful approval of a …

Amorphous solid dispersions (ASDs) are often metastable against crystallization of the
active pharmaceutical ingredient (API) and thus might undergo unwanted changes during …

The use of amorphous solid dispersions (ASDs) in commercial drug products has increased
in recent years due to the large number of poorly soluble drugs in the pharmaceutical …

Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

Amorphous solid dispersions (ASDs) with solubility advantage are suffering from the
recrystallization risk and subsequent reduced dissolution triggered by high hygroscopicity of …

Abstract Formulation of an amorphous solid dispersion (ASD) is one of the methods
commonly considered to increase the bioavailability of a poorly water-soluble small …