Diabetic nephropathy is one of the most common microvascular complications of diabetes
mellitus and the leading cause of end-stage renal disease in developed countries. Current …

Amid the rapidly rising number of people with diabetes worldwide, the prevalence of diabetic
kidney disease (DKD) is expected to increase considerably despite available treatments …

Protein kinase C β inhibition: the promise for treatment of... : Current Opinion in Nephrology
and Hypertension Protein kinase C β inhibition: the promise for treatment of diabetic …

Background. Activation of protein kinase C (PKC) has been implicated in the pathogenesis
of diabetic nephropathy where therapy targeting the β isoform of this enzyme is in advanced …

In addition to hyperglycemia, hypertension and the renin-angiotensin system have been
consistently implicated in the pathogenesis of diabetic nephropathy. Each of these …

Activation of protein kinase C (PKC) has been implicated in the pathogenesis of diabetic
nephropathy with proteinuria and peritubular extracellular matrix production. We have …

Although treatments for diabetic kidney disease are available, many patients still have
progressive disease. More effective therapies are urgently needed. Novel agents currently …

Activation of protein kinase C (PKC) is implicated as an important mechanism by which
diabetes causes vascular complications. We have recently shown that a PKC β inhibitor …

Ruboxistaurin is an inhibitor of the β isoform of protein kinase C (PKC-β) that reduces the
actions of vascular endothelial growth factor (VEGF) and attenuates the progression of …

The protein kinase C (PKC)-β isoform has been implicated to play a pivotal role in the
development of diabetic kidney disease. We tested this hypothesis by inducing diabetic …