Hepatocellular carcinoma (HCC) occurs more frequently in men than in women. It is
commonly agreed that estrogen plays important roles in suppressing HCC development …

Estrogens have been proposed to act as tumor promoters and induce
hepatocarcinogenesis. Recently, we observed a significant association between the risk for …

Hepatocellular carcinoma (HCC) that is triggered by metabolic defects is one of the most
malignant liver cancers. A much higher incidence of HCC among men than women suggests …

Abstract Cytochrome P450 (CYP) 1A1 plays a major role in the metabolic activation of
procarcinogens to carcinogens via aryl hydrocarbon receptor (AhR) pathway. Especially, 2 …

Abstract Background and Aim: While gender differences in hepatocellular carcinoma (HCC)
are profound, the mechanism is unclear. Using castration and hormone replacement …

Objects The incidence of hepatocellular carcinoma (HCC) shows an obvious male
dominance in rodents and humans. We aimed to identify the key autosomal liver-specific sex …

Abstract Purpose 2-Methoxyestradiol (2-ME) is a physiological metabolite of estrogen, which
can inhibit growth of many types of tumor cells, including hepatocellular carcinoma, both in …

Simple Summary Today, we know that estrogen hormones are required for the development
and function of many organs, such as the liver, in both males and females. However, in …

CYP2E1 is of paramount toxicological significance because it metabolically activates a large
number of low-molecular-weight toxicants and carcinogens. In this context, factors that …

There are significant gender differences in the incidence and mortality of hepatocellular
carcinoma (HCC). Compared with men, the incidence and mortality of HCC in women are …