Purpose We evaluated in vitro the role of CO 2-induced oxidative stress on the expression of
proteins involved in cell-cycle regulation of neuroblastoma cells. Methods SH-SY5Y cells …

Background The response of mesothelial cells to surgical trauma and bacterial
contamination is poorly defined. We have recently shown that CO 2 pneumoperitoneum …

Introduction CO 2 pneumoperitoneum can influence the biological behavior of
neuroblastoma (NB). Angiogenesis and genetic features are responsible for malignant …

The ablative role of minimally invasive surgery (MIS) in neuroblastoma (NB) is still
controversial due to the possible CO₂ pneumoperitoneum side-effects on tumor …

In search for innovative therapeutic agents for children neuroblastoma, the oxygen therapy
could be considered an alternative anti‐tumoral treatment. Given the physiochemical …

Purpose: It has been reported that CO 2 gas, used to establish a pneumoperitoneum during
laparoscopy, affects the behavior of tumor cells. The proto-oncogenes c-myc and HMGB-1 …

RESULTS: The oxidative stress to U251 glioma cells exhibited in a dose-dependent manner
with H2O2 concentrations increasing. The cell viability was considerably decreased and …

Background Reactive oxygen species (ROS) contribute to adult tumorigenesis; however,
their roles in pediatric solid tumors are unknown. Here, we sought to define the steady-state …

The process of cell differentiation goes hand‐in‐hand with metabolic adaptations, which are
needed to provide energy and new metabolites. Carbon monoxide (CO) is an endogenous …

The developing brain is vulnerable to environmental factors. We investigated the effects of
air that contained 0.05, 0.1 and 0.3% CO2 on the hippocampus, prefrontal cortex (PFC) and …