Hepatocyte apoptosis is a hallmark of nonalcoholic steatohepatitis. We have previously
observed that the saturated free fatty acids (FFAs) induce hepatocyte apoptosis in part via a …

The pathogenesis of nonalcoholic steatohepatitis (NASH) is unclear, despite
epidemiological data implicating FFAs. We studied the pathogenesis of NASH using …

Elevated serum free fatty acids (FFAs) and hepatocyte lipoapoptosis are features of non-
alcoholic fatty liver disease. However, the mechanism by which FFAs mediate lipoapoptosis …

Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, which results
in elevated serum concentration of free fatty acids (FFAs). Circulating FFAs provide the …

Delivery of free fatty acids to the liver in nonalcoholic fatty liver disease (NAFLD) may render
hepatocytes more vulnerable to glycochenodeoxycholic acid (GCDCA)-induced apoptosis …

Fatty acid-induced lipotoxicity plays a critical role in the pathogenesis of nonalcoholic liver
disease. Saturated fatty acids and unsaturated fatty acids have differential effects on cell …

Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, elevated
serum levels of free fatty acids (FFAs) and fatty infiltration of the liver. Accumulation of …

Background & aims: Hepatocyte apoptosis is a key event in non‐alcoholic steatohepatitis
(NASH). We studied the effect of obesity on free fatty acid (FFA) levels, fatty acid transport …

Insulin is known to induce hepatocyte swelling, which triggers via integrins and c-Src kinase
an activation of the epidermal growth factor receptor (EGFR) and subsequent cell …

Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease
(NAFLD) with portal inflammation and ductular reaction. Based on reports of biliary damage …