The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel
agents or combination-based analgesic therapies are needed. Herein, oral tolperisone …

Current treatment approaches to manage neuropathic pain have a slow onset and their use
is largely hampered by side-effects, thus there is a significant need for finding new …

ABSTRACT Preclinical Research Treatment of neuropathic pain is an area of largely unmet
medical need. Pregabalin and gabapentin are anticonvulsants widely used for the treatment …

Chronic pain is a common public health problem and remains an unmet medical need.
Currently available analgesics usually have limited efficacy for the treatment of chronic pain …

Purpose: There is a strong medical demand to search for novel, more efficacious and safer
than available, analgesics for the treatment of neuropathic pain. This study investigated …

BACKGROUND: Neuropathic pain should be treated with drug combinations exhibiting
multiple analgesic mechanisms of action because the mechanism of neuropathic pain …

Pregabalin has been increasingly used in recent years, and becoming a first-line medication
for the clinical treatment of neuropathic pain. However, the mechanisms underlying …

Background: Amitriptyline, duloxetine, and pregabalin are among the most
pharmacotherapeutic, effective treatments for neuropathic pain control. However, the …

Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have
been reported to effectively decrease neuropathic pain by inhibiting the activity of …

Objective: The thiamin is often used in the treatment of neuropathy, and pregabalin is often
used to treat neuropathic pain. Our study examined the influence of thiamin on the efficacy of …