Aims/hypothesis Both leptin and insulin sensitivity have been linked with pathophysiological
processes involving the central nervous system in general, and the hippocampus in …

Amylin acts acutely via the area postrema to reduce food intake and body weight, but it also
interacts with leptin over longer periods of time, possibly via the ventromedial hypothalamus …

Aims/hypothesis It has been suggested that amylin amplifies leptin's effects and affects
energy homeostasis synergistically with leptin in animals and humans. However, no …

While the regulation of energy homeostasis by amylin is already well-characterized,
emerging data suggest that amylin is also crucial for the development of neural pathways in …

Leptin is a pleiotropic hormone primarily secreted by adipocytes. A high density of functional
Leptin receptors has been reported to be expressed in the hippocampus and other cortical …

Leptin, which serves as a lipid-modulating hormone to control metabolic energy availability,
is decreased in Alzheimer's disease (AD) patients, and serum levels are inversely correlated …

Obese individuals exhibit altered circulating levels of adipokines, the proteins secreted by
adipose tissue to mediate tissue cross-talk and regulate appetite and energy expenditure …

We have previously demonstrated that Leptin reduces extracellular amyloid β (Aβ) protein
both in vitro and in vivo, and intracellular tau phosphorylation in vitro. Further, we have …

Leptin, an adipose-derived hormone, has been implicated in several physiological
processes involving the hippocampus. However, the role of leptin in adult hippocampal …

Amylin acts in the area postrema (AP) and arcuate nucleus (ARC) to control food intake.
Amylin also increases axonal fiber outgrowth from the AP→ nucleus tractus solitarius and …