The transcription factor Evi1 has an outstanding role in the formation and transformation of
hematopoietic cells. Its activation by chromosomal rearrangement induces a …

Evi-1 has been recognized as one of the dominant oncogenes associated with murine and
human myeloid leukemia. Here, we show that hematopoietic stem cells (HSCs) in Evi-1 …

One of the genes associated with both murine and human myeloid leukemia is EVI1
(ecotropic viral integration 1 site). EVI1 was first identified as a common locus of retroviral …

The transcriptional regulator EVI1 has an essential role in early hematopoiesis and
development. However, aberrantly high expression of EVI1 has potent oncogenic properties …

Evi-1 is a transcription factor with two sets of zinc finger domains. The temporally and
spatially restricted pattern of Evi-1 expression in embryonic tissues suggests a role of Evi-1 …

The ecotropic viral integration site 1 (EVI1) gene was identified almost 20 years ago as the
integration site of an ecotropic retrovirus leading to murine myeloid leukemia. Since its …

Background and Aim: Overexpression of ecotropic viral integration site 1 (EVI1) is
associated with aggressive disease in myeloid leukemia. We therefore studied its …

Relapse of chronic myeloid leukemia (CML) is triggered by stem cells with a reconstituting
capacity similar to that of hematopoietic stem cells (HSCs) and CML stem cells are a source …

The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal
development and in leukemogenesis. Transcriptional activation of this gene through …

Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disease of early
childhood, that is peculiarly characterized by the ability of bone marrow progenitors to …