Neuropathic pain may be produced, at least in part, by the increased activity of primary
afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium …

The novel sodium channel PN3/α-SNS, which was cloned from a rat dorsal root ganglion
(DRG) cDNA library, is expressed predominantly in small sensory neurons and may …

The tetrodotoxin-resistant (TTX-R) voltage-gated sodium channel SNS/PN3 and the newly
discovered NaN/SNS2 are expressed in sensory neurones, particularly in nociceptors …

Two tetrodotoxin-resistant voltage-gated sodium channels, SNS/PN3 and SNS2/NaN, have
been described recently in small-diameter sensory neurones of the rat, and play a key role …

Alterations in sodium channel expression and function have been suggested as a key
molecular event underlying the abnormal processing of pain after peripheral nerve or tissue …

Small neurons of the dorsal root ganglia (DRG) are known to play an important role in
nociceptive mechanisms. These neurons express two types of sodium current, which differ in …

Although hyperexcitability and/or increased baseline sensitivity of primary sensory neurons
following nerve injury can lead to abnormal burst activity associated with pain, the molecular …

The nine members of the voltage-gated sodium channel (Nav) family mediate inward
sodium currents that depolarize neurons and lead to action potential firing. Increased Nav …

Voltage‐gated sodium channels underlie the generation of action potentials in excitable
cells. Various sodium channel isoforms have been cloned, functionally expressed and …

Voltage-gated sodium channels consist of a pore-containing α-subunit and one or more
auxiliary β-subunits, which may modulate channel function. We previously demonstrated …