Pathways that control aging act via regulated biochemical processes, among which
metabolism of xenobiotics (potentially harmful chemical agents encountered as …

Our previous microarray expression analysis of the long‐lived Little mice (Ghrhrlit/lit)
showed a concerted up‐regulation of xenobiotic detoxification genes. Here, we show that …

Activation of xenobiotic metabolism pathways has been linked to lifespan extension in
different models of aging. However, the mechanisms underlying activation of xenobiotic …

Aged rodents show increasing plasma and tissue triglycerides, and reductions in liver
peroxisome proliferator-activated receptor α (PPARα) and its target genes. We determined …

Health during aging can be improved by genetic, dietary and pharmacological interventions.
Many of these increase resistance to various stressors, including xenobiotics. Up-regulation …

Bile acids are detergent molecules derived from cholesterol in the liver that are important for
the metabolism and absorption of lipids in the intestine. Bile acids are also steroid hormones …

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …

Aging impairs organismal homeostasis leading to multiple pathologies. Yet, the mechanisms
and molecular intermediates involved are largely unknown. Here, we report that aged aryl …

Decreased somatotrophic signaling is among the most important mechanisms associated
with extended longevity. Mice homozygous for the targeted disruption of the growth hormone …

Publisher Summary The somatotropic hormone axis has been implicated in the regulation of
aging processes and life span. This chapter indicates that interfering with signaling at …