[HTML][HTML] Preparation of 6/8/11-amino/chloro-oxoisoaporphine and group-10 metal complexes and evaluation of their in vitro and in vivo antitumor activity
QP Qin, JL Qin, T Meng, GA Yang, ZZ Wei, YC Liu… - Scientific Reports, 2016 - nature.com
A series of group-10 metal complexes 1–14 of oxoisoaporphine derivatives were designed
and synthesized. 1–14 were more selectively cytotoxic to Hep-G2 cells comparing with …
and synthesized. 1–14 were more selectively cytotoxic to Hep-G2 cells comparing with …
[HTML][HTML] Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2
JL Qin, WY Shen, ZF Chen, LF Zhao, QP Qin, YC Yu… - Scientific reports, 2017 - nature.com
Three new oxoaporphine Co (II), Ni (II) and Zn (II) complexes 1–3 have been synthesized
and fully characterized. 1–3 have similar mononuclear structures with the metal and ligand …
and fully characterized. 1–3 have similar mononuclear structures with the metal and ligand …
High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions
QP Qin, JL Qin, T Meng, WH Lin, CH Zhang… - European Journal of …, 2016 - Elsevier
Two G-quadruplex ligands:[Co (HL a) 2 Cl 2](Co1) and [Co (L b) 2][CoCl 4]⋅ 2H 2 O (Co2)
have been synthesized and characterized. Two cobalt oxoisoaporphine complexes …
have been synthesized and characterized. Two cobalt oxoisoaporphine complexes …
5-Bromo-oxoisoaporphine platinum (II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and …
ZZ Wei, QP Qin, T Meng, CX Deng, H Liang… - European Journal of …, 2018 - Elsevier
Two platinum (II) complexes [Pt (L)(DMSO) Cl](1) and [Pt (L)(pn)] Cl (2) with 5-bromo-
oxoisoaporphine (HL) were synthesized. We found that the two new platinum (II) complexes …
oxoisoaporphine (HL) were synthesized. We found that the two new platinum (II) complexes …
One-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions
LS Liao, LJ Tan, Y Chen, QY Yang… - European Journal of …, 2022 - Elsevier
An efficient one-pot reaction for the synthesis of oxoaporphine alkaloids has been
developed. Twenty-three compounds of oxoaporphine alkaloids were prepared and …
developed. Twenty-three compounds of oxoaporphine alkaloids were prepared and …
Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells
H Zhong, M Zhao, C Wu, J Zhang, L Chen… - European Journal of …, 2022 - Elsevier
A series of oxoisoaporphine derivatives with topoisomerase I inhibition and cytotoxic
activities. Among them, compound 14 showed the most potent cytotoxic activity against all …
activities. Among them, compound 14 showed the most potent cytotoxic activity against all …
Ni (II), Cu (II) and Zn (II) complexes with the 1-trifluoroethoxyl-2, 9, 10-trimethoxy-7-oxoaporphine ligand simultaneously target microtubules and mitochondria for …
LS Liao, Y Chen, ZY Mo, C Hou, GF Su… - Inorganic Chemistry …, 2021 - pubs.rsc.org
Metal complexes of [NiL2 (NO3) 2](1),[CuL2 (NO3) 2](2) and [ZnL2 (NO3) 2](3) with the 1-
trifluoroethoxyl-2, 9, 10-trimethoxy-7-oxoaporphine (L) ligand were synthesized. We …
trifluoroethoxyl-2, 9, 10-trimethoxy-7-oxoaporphine (L) ligand were synthesized. We …
Synthesis, Crystal Structure, Cytotoxicity, and Mechanism of Action of ZnII, MnII, and FeIII Complexes with 6‐Hydroxyloxoisoaporphine
QP Qin, T Meng, ZZ Wei, CH Zhang… - European Journal of …, 2017 - Wiley Online Library
Complexes [Zn (L) 2 (H2O)](1),[Mn (L) 2 (CH3OH) 2](2), and [Fe (L) 2 (CH3OH) Cl](3)(H–L=
6‐hydroxyloxoisoaporphine) were synthesized and characterized. Complex 1 is a five …
6‐hydroxyloxoisoaporphine) were synthesized and characterized. Complex 1 is a five …
[HTML][HTML] Oxoisoaporphines and aporphines: Versatile molecules with anticancer effects
E Rodríguez-Arce, P Cancino, M Arias-Calderón… - Molecules, 2019 - mdpi.com
Cancer is a disease that involves impaired genome stability with a high mortality index
globally. Since its discovery, many have searched for effective treatment, assessing different …
globally. Since its discovery, many have searched for effective treatment, assessing different …
Oxoisoaporphine alkaloid derivatives: Synthesis, DNA binding affinity and cytotoxicity
H Tang, XD Wang, YB Wei, SL Huang… - European journal of …, 2008 - Elsevier
A series of novel oxoisoaporphine alkaloid derivatives, 9-aminoalkanamido-1-
azabenzanthrone (general formula Ar–NHCO (CH2) nNR2, Ar= 1-azabenzanthrone, n= 1, 2 …
azabenzanthrone (general formula Ar–NHCO (CH2) nNR2, Ar= 1-azabenzanthrone, n= 1, 2 …