Rhizoxin is an antineoplastic drug that inhibits tubulin polymerization. In this study, we
demonstrated that rhizoxin was approximately twice as active in vitro against a human small …

Rhizoxin is a 16-membered antifungal macro-cyclic lactone isolated from the plant
pathogenic fungus Rhizopus chinensis. The compound binds to tubulin, preventing …

We established a vindesine-resistant (x 11.6) human small-cell lung cancer cell line
(H69/VDS) by stepwise exposure of parent line H69 to vindesine. H69/VDS showed cross …

Studies on vinca domain binding drugs were done in great details by a number of workers
as it is recognized as a potential target for anticancer drug development. Their structures …

Vinorelbine, a semi-synthetic vinca alkaloid, is widely used for the treatment of non-small
cell lung cancer, metastatic breast cancer and ovarian cancer by inhibiting microtubule …

Rhizoxin is a new macrocyclic lactone isolated from the fungus Rhizopus chinensis. In an
attempt to predict the effectiveness of rhizoxin in the treatment of lung cancer, we compared …

Background Rhizoxin (NSC 332598) is a novel macrolide antitumor antibiotic that inhibits
microtubule assembly and also depolymerizes preformed microtubules. In preclinical …

Abstract C58 Eribulin (E7389, ER-086526, NSC-707389), a structurally-simplified synthetic
analog of the biologically active macrocyclic portion of the marine natural product …

We have previously established a vincristine resistant human lung cancer cell line (PC-
9/VCR) by a stepwise exposure of parental line PC-9 to vincristine. In this study the resistant …

A multidrug-resistant lymphoma cell line resistant to 1.0 μM vincristine (designated
HOB1/VCR1. 0) was established. The tubulins of parental and resistant cell Lines mere …