[HTML][HTML] Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
[HTML][HTML] Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank
Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …
Mosaic Y loss is moderately associated with solid tumor risk
Mosaic loss of the Y chromosome (mLOY) in peripheral leukocytes is a somatic event in
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …
[HTML][HTML] Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
M Danielsson, J Halvardson, H Davies… - European Journal of …, 2020 - nature.com
Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is
associated with increased risk for all-cause mortality, various forms of cancer and …
associated with increased risk for all-cause mortality, various forms of cancer and …
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer
LA Forsberg, C Rasi, N Malmqvist, H Davies… - Nature …, 2014 - nature.com
Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is
largely unexplained,. Furthermore, age-related loss of chromosome Y (LOY) is frequent in …
largely unexplained,. Furthermore, age-related loss of chromosome Y (LOY) is frequent in …
[HTML][HTML] A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells
Background Mosaic loss of Y chromosome (LOY) is the most common somatic change that
occurs in circulating white blood cells of older men. LOY in leukocytes is associated with …
occurs in circulating white blood cells of older men. LOY in leukocytes is associated with …
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
The Y chromosome is frequently lost in hematopoietic cells, which represents the most
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …
Mosaic loss of Y chromosome in white blood cells: its impact on men's health
We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the
known risk factors for this condition. We then overview the associations between LOY and …
known risk factors for this condition. We then overview the associations between LOY and …
[HTML][HTML] GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
C Terao, Y Momozawa, K Ishigaki, E Kawakami… - Nature …, 2019 - nature.com
Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
Mosaic loss of human Y chromosome: what, how and why
Y chromosome (ChrY), the male-specific sex chromosome, has been considered as a
genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has been known for more than …
genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has been known for more than …