Rai (ShcC) belongs to the family of Shc adaptor proteins and is expressed in neuronal cells,
where it acts as a survival factor activating the PI3K/Akt survival pathway. In vivo, Rai …

Rai/ShcC is a member of the Shc family of protein adaptors expressed with the highest
abundance in the central nervous system, where it exerts a protective function by coupling …

Autoimmunity (AI) exemplifies the potent and destructive activity expressed by the immune
system when normal constraints against self-reactivity are lost or compromised. We have …

Rai prevents lupus nephritis by impairing the development and expansion of both
proinflammatory Th17 and Th1 cells. Rai, a Shc adapter family member, acts as a negative …

Major histocompatibility complex (MHC) class I1 glycoprotein antigens expressed on
antigen-presenting cells play a critical role in L3T4+ T-cell proliferation and TB interactions …

Patients with mutations of the recombination-activating genes (RAG) present with diverse
clinical phenotypes, including severe combined immune deficiency (SCID), autoimmunity …

Patients with mutations of the recombination-activating genes (RAG) present with diverse
clinical phenotypes, including severe combined immune deficiency (SCID), autoimmunity …

Recent investigations into gene function in mice have revealed that the absence, or
abnormal expression, of a variety of proteins, leads to pathology similar to that observed in …

Background The significance of a unique inhibitory Fc receptor for IgG, FcγRIIB (RIIB), in the
prevention of spontaneous production of autoantibodies remains controversial, due mainly …

This is especially relevant when studying the immune system in hypertension because both
the immune response and development of hypertension have been causally and …