BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in
aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase …

NUT carcinoma (NC), characterized most commonly by the BRD4-NUTM1 fusion, is a rare,
aggressive variant of squamous carcinoma with no effective treatment. BRD4-NUT drives …

NUT midline carcinoma (NMC) is a rare but highly aggressive cancer typically caused by the
translocation t (15; 19), which results in the formation of the BRD4-NUT fusion oncoprotein …

NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy.
NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines …

Defects in chromatin proteins frequently manifest in diseases. A striking case of a chromatin-
centric disease is NUT-midline carcinoma (NMC), which is characterized by expression of …

NUT midline carcinoma (NMC) belongs to a class of highly lethal and poorly differentiated
epithelial cancers arising mainly in human midline organs. NMC is caused by the …

To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT
midline carcinoma (NMC), we have identified protein interactions unique to the BRD4–NUT …

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …

NUT midline carcinoma (NMC) is a lethal pediatric tumor defined by the presence of BRD-
NUT fusion proteins that arrest differentiation. Here we explore the mechanisms underlying …

NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is
defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins …