Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis

Q Jia, BY Lee, DL Clemens, RA Bowen, MA Horwitz - Vaccine, 2009 - Elsevier
Fransicella tularensis, the causative agent of tularemia, is in the top category (Category A) of
potential agents of bioterrorism. To develop a safer vaccine against aerosolized F …

A Heterologous Prime-Boost Vaccination Strategy Comprising the Francisella tularensis Live Vaccine Strain capB Mutant and Recombinant Attenuated Listeria …

Q Jia, R Bowen, J Sahakian, BJ Dillon… - Infection and …, 2013 - Am Soc Microbiol
Francisella tularensis, the causative agent of tularemia, is a category A bioterrorism agent. A
vaccine that is safer and more effective than the currently available unlicensed F. tularensis …

[HTML][HTML] Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis

Q Jia, MA Horwitz - Frontiers in cellular and infection microbiology, 2018 - frontiersin.org
Francisella tularensis is the causative agent of tularemia and a Tier I bioterrorism agent. In
the 1900s, several vaccines were developed against tularemia including the killed “Foshay” …

A Francisella tularensis Live Vaccine Strain (LVS) Mutant with a Deletion in capB, Encoding a Putative Capsular Biosynthesis Protein, Is Significantly More Attenuated than LVS …

Q Jia, BY Lee, R Bowen, BJ Dillon, SM Som… - Infection and …, 2010 - Am Soc Microbiol
Francisella tularensis, the causative agent of tularemia, is in the top category (category A) of
potential agents of bioterrorism. The F. tularensis live vaccine strain (LVS) is the only …

Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensis

R KuoLee, G Harris, JW Conlan, W Chen - Vaccine, 2007 - Elsevier
Francisella tularensis is a Gram-negative intracellular bacterium, and the causative agent of
tularemia. The infection can be initiated by various routes and can manifest itself in several …

Diverse Myeloid and Lymphoid Cell Subpopulations Produce Gamma Interferon during Early Innate Immune Responses to Francisella tularensis Live Vaccine Strain

R De Pascalis, BC Taylor, KL Elkins - Infection and immunity, 2008 - Am Soc Microbiol
Francisella tularensis, a small gram-negative intracellular bacterium responsible for causing
tularemia, is highly pathogenic and classified as a category A agent of bioterrorism. As for …

Native Outer Membrane Proteins Protect Mice against Pulmonary Challenge with Virulent Type A Francisella tularensis

JF Huntley, PG Conley, DA Rasko… - Infection and …, 2008 - Am Soc Microbiol
Francisella tularensis is a gram-negative intracellular bacterium and the causative agent of
the zoonotic disease tularemia. F. tularensis is a category A select agent and thus a potential …

Oral Live Vaccine Strain-Induced Protective Immunity against Pulmonary Francisella tularensis Challenge Is Mediated by CD4+ T Cells and Antibodies, Including …

HJ Ray, Y Cong, AK Murthy, DM Selby… - Clinical and Vaccine …, 2009 - Am Soc Microbiol
Francisella tularensis is an intracellular gram-negative bacterium and the etiological agent
of pulmonary tularemia. Given the high degrees of infectivity in the host and of dissemination …

Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly …

JW Conlan, H Shen, R KuoLee, X Zhao, W Chen - Vaccine, 2005 - Elsevier
Francisella tularensis is an extremely virulent facultative intracellular bacterial pathogen of
many mammalian species including mice and humans in which it causes a spectrum of …

Immunization with heat‐killed Francisella tularensis LVS elicits protective antibody‐mediated immunity

CL Lavine, SR Clinton… - European journal of …, 2007 - Wiley Online Library
Francisella tularensis (FT) has been classified by the CDC as a category A pathogen
because of its high virulence and the high mortality rate associated with infection via the …