Objectives: To determine the effects of calcium antagonists on hyperinsulinemia,
hypertriglyceridemia and hypertension, we examined the long-term effects of a new calcium …

OBJECTIVE: Numerous recent studies suggest that abnormal intracellular calcium
concentration ([Ca2+] i) is a common defect in diabetic animal models and patients …

To investigate whether the long-acting Ca channel blocker, benidipine improves insulin
resistance in patients with essential hypertension, insulin sensitivity was measured using the …

Mibefradil and amlodipine are calcium antagonists with different channel selectivities.
Mibefradil blocks both L-and T-type calcium channels; although in the usual …

The effects of calcium channel blockers (CCB)-verapamil, nifedipine, diltiazem on metabolic
control in streptozotocin-induced long-term diabetes in rats were investigated. Diabetes …

Background To explore the metabolic actions of nifedipine on diabetes, we examined
glucose intolerance and white adipose tissue changes in type 2 diabetic KK-Ay mice …

Among the antihypertensive drugs, fast-acting Ca 2+ antagonists have been reported to
worsen insulin sensitivity. This effect may be attributable to reflex increases in sympathetic …

Background: Calcium channel blockers are commonly used to treat hypertension, and are
known to generally act on the L-type calcium channel. Recent studies have shown, however …

Objective: Calcium channel antagonists (CCA) have been proposed for the prevention of
cardiac events after myocardial infarction (MI). Mibefradil is a CCA featuring a selective …

Background Although effective in reducing blood pressure, therapy with a first-generation β-
blocker is currently controversial in metabolic syndrome due to its negative impact on …