[HTML][HTML] A broad and potent H1-specific human monoclonal antibody produced in plants prevents influenza virus infection and transmission in guinea pigs

JG Park, C Ye, MS Piepenbrink, A Nogales, H Wang… - Viruses, 2020 - mdpi.com
Although seasonal influenza vaccines block most predominant influenza types and
subtypes, humans still remain vulnerable to waves of seasonal and new potential pandemic …

[HTML][HTML] Human monoclonal antibodies neutralizing influenza virus A/H1N1pdm09 and seasonal A/H1N1 strains–Distinct Ig gene repertoires with a similar action …

S Hiroi, M Kuhara, Y Kishi, K Ono, S Matsuzawa… - Immunobiology, 2018 - Elsevier
Influenza virus causes acute respiratory infection in humans, and is a major public health
concern globally. Antibodies play a central role in host protection against influenza virus. We …

[HTML][HTML] A highly potent and broadly neutralizing H1 influenza-specific human monoclonal antibody

A Nogales, MS Piepenbrink, J Wang, S Ortega… - Scientific reports, 2018 - nature.com
Influenza's propensity for antigenic drift and shift, and to elicit predominantly strain specific
antibodies (Abs) leaves humanity susceptible to waves of new strains with pandemic …

[HTML][HTML] Prophylactic and therapeutic efficacy of avian antibodies against influenza virus H5N1 and H1N1 in mice

HH Nguyen, TM Tumpey, HJ Park, YH Byun, LD Tran… - PloS one, 2010 - journals.plos.org
Background Pandemic influenza poses a serious threat to global health and the world
economy. While vaccines are currently under development, passive immunization could …

Human monoclonal antibodies derived from a patient infected with 2009 pandemic influenza A virus broadly cross-neutralize group 1 influenza viruses

Y Pan, T Sasaki, R Kubota-Koketsu, Y Inoue… - Biochemical and …, 2014 - Elsevier
Influenza viruses are a continuous threat to human public health because of their ability to
evolve rapidly through genetic drift and reassortment. Three human monoclonal antibodies …

Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza A virus subtype H5N1

S Maneewatch, J Thanongsaksrikul… - Antiviral …, 2009 - journals.sagepub.com
Background Human antibodies that interfere with the biological activity of haemagglutinins
(HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single …

In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus …

TC Sutton, EW Lamirande, KW Bock, IN Moore… - Journal of …, 2017 - Am Soc Microbiol
Influenza viruses of the H1N1, H2N2, and H3N2 subtypes have caused previous
pandemics. H2 influenza viruses represent a pandemic threat due to continued circulation in …

Broadly reactive human monoclonal antibodies elicited following pandemic H1N1 influenza virus exposure protect mice against highly pathogenic H5N1 challenge

R Nachbagauer, D Shore, H Yang, SK Johnson… - Journal of …, 2018 - Am Soc Microbiol
Broadly cross-reactive antibodies (Abs) that recognize conserved epitopes within the
influenza virus hemagglutinin (HA) stalk domain are of particular interest for their potential …

[HTML][HTML] Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice

S Son, SB Ahn, G Kim, Y Jang, C Ko, M Kim, SJ Kim - Antiviral Research, 2023 - Elsevier
Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus
enable it to cross the species barrier, threatening public health with the risk of pandemics …

Human monoclonal antibody derived from transchromosomic cattle neutralizes multiple H1 clades of influenza A virus by recognizing a novel conformational epitope …

R Gao, CC Sreenivasan, Z Sheng, BM Hause… - Journal of …, 2020 - Am Soc Microbiol
Influenza remains a global health risk and challenge. Currently, neuraminidase (NA)
inhibitors are extensively used to treat influenza, but their efficacy is compromised by the …