The high morbidity and mortality rate of ischemic stroke in humans has led to the
development of numer ous animal models that replicate human stroke to further understand …

The high morbidity and mortality rate of ischemic stroke in humans has led to the
development of numerous animal models that replicate human stroke to further understand …

Translation of acute ischemic stroke research to the clinical setting remains limited over the
last few decades with only one drug, recombinant tissue-type plasminogen activator …

This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

Translation from basic science bench research in ischemic stroke to bedside treatment of
patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

Stroke is a leading cause of death and disability worldwide. Effective intervention for acute
stroke remains to be a significant unmet medical need. In the past several decades, a large …

Stroke has been identified as the second leading cause of death worldwide. Stroke is a focal
neurologic deficit caused by a change in cerebral circulation. The use of animal models in …

Stroke remains the second leading cause of death worldwide and the third cause of
disability-adjusted life-years. Most strokes are ischemic in nature, meaning they are caused …

Recanalization therapy with endovascular procedures has led to significant advances in the
treatment of acute ischemic stroke. Animal models have been the basis for enhancing the …