Although the role of oxidative stress in maternal aging and infertility has been suggested, the
underlying mechanisms are not fully understood. The present study is designed to …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …

Mammalian oocytes are long-lived cells in the human body. They initiate meiosis already in
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …

Object To explore the mechanisms of ovarian aging, we performed overall analysis on the
age-related alterations of gene expression profiles in mouse germinal vesicle (GV) stage …

OBJECTIVE (S): To examine the effect of exogenous exposure to hydrogen peroxide (H2O2)
and tumor necrosis factor (TNF)-α on mouse metaphase II (MII) oocyte spindle structure and …

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …

Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte.
Oxidative stress is one of the most detrimental factors affecting oocyte developmental …

STUDY QUESTION Do mitochondria-targeted therapies reverse ageing-and oxidative stress-
induced spindle defects in oocytes from mice and humans? SUMMARY ANSWER Exposure …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …