The B→ Z transition of DNA modified by platinum (II) complexes has attracted considerable
interest because of a possible relationship with the molecular mechanism of antitumor …

It has been shown recently that some analogues of clinically ineffective trans-
diamminedichloroplatinum (II)(transplatin) exhibit antitumor activity. This finding has inverted …

Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2 (E-
iminoether) 2], exhibits antitumor activity has helped reevaluation of the empirical structure …

In this work, the B→ Z transition of poly (dG-dC)· poly (dG-dC) and the B→ A transition of
poly (dG)· poly (dC) and of calf thymus (CT) DNA fragments modified by antitumor …

We present data demonstrating that the cytotoxic compound [Pt2Cl4 (diminazene aceturate)
2] Cl4· 4H2O (Pt-berenil) circumvents cisplatin resistance in ovarian carcinoma cells. The …

The global modification of mammalian and plasmid DNAs by novel platinum compounds,
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …

The structure–pharmacological activity relationships generally accepted for antitumor
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …

The biological activity of cm and trans complexes of formula [PtCl2 [HN C (OMe) Me] 2] has
been investigated. The iminoether ligands can have either E or Z configuration about the C …

The single-stranded oligonucleotide 5′-d (CCTCGCTCTC)(I) was reacted with the
antitumor trans platinum iminoderivative trans-[PtCl 2 {E-HN= C (OMe) Me} 2](trans-EE) and …

Most of the structure/activity rules emerged from the initial studies by Rosenberg and Cleare
and Hoeschele have now been questioned. Specifically:(i) trans compounds are inactive,(ii) …