BACKGROUND: Delayed onset of efficacy of antidepressants and a high proportion of
depressed patients being poor or non-responders to antidepressants are well known clinical …

Early improvement of depressive symptoms during the first two weeks of antidepressant
treatment has been discussed to be a resilience signal predicting a later positive treatment …

OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

BACKGROUND: The duration of untreated illness has been considered a likely predictor of
the course of psychotic disorders. However, there is only sparse data concerning the …

Objective: Antidepressants (ADs) are the mainstay of treatment for major depressive
disorder (MDD). Despite their widespread usage, a consensus does not exist as to the …

Objective The role of baseline severity as effect modifier in various psychiatric disorders is a
topic of controversy and of clinical import. This study aims to examine whether baseline …

Objective: New evidence indicates that treatment response can be predicted with high
sensitivity after 2 weeks of treatment. Here, we assess whether early improvement with …

BACKGROUND: Although antidepressants are conventionally given for 4–6weeks before
deciding on response, several reports suggest that early improvement predicts later …

Background Initial improvement in the first weeks of antidepressant (AD) treatment is a
useful early predictor of complete AD response. We performed a meta-analysis of AD …

BackgroundImprovement in depression within the first 2 weeks of antidepressant treatment
predicts good outcomes, but non-improvers can still respond or remit, whereas improvers …