Use of differentiated pluripotent stem cells in replacement therapy for treating disease
BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …
[HTML][HTML] Induced pluripotent stem cells, a giant leap for mankind therapeutic applications
J Bragança, JA Lopes, L Mendes-Silva… - World journal of stem …, 2019 - ncbi.nlm.nih.gov
Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells
biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer …
biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer …
Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells
DS Kaufman - Blood, The Journal of the American Society of …, 2009 - ashpublications.org
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide
remarkable cellular platforms to better understand human hematopoiesis and to develop …
remarkable cellular platforms to better understand human hematopoiesis and to develop …
Pluripotent stem cells progressing to the clinic
A Trounson, ND DeWitt - Nature reviews Molecular cell biology, 2016 - nature.com
Basic experimental stem cell research has opened up the possibility of many diverse clinical
applications; however, translation to clinical trials has been restricted to only a few diseases …
applications; however, translation to clinical trials has been restricted to only a few diseases …
Pluripotent stem cells in regenerative medicine: challenges and recent progress
After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …
[HTML][HTML] Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations
S Moradi, H Mahdizadeh, T Šarić… - … cell research & …, 2019 - stemcellres.biomedcentral.com
Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …
into all specialized cell types including gametes. iPSCs do not exist naturally and are …
Autologous induced pluripotent stem cell–based cell therapies: promise, progress, and challenges
M Madrid, C Sumen, S Aivio, N Saklayen - Current protocols, 2021 - Wiley Online Library
The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …
The safety of human pluripotent stem cells in clinical treatment
OE Simonson, A Domogatskaya, P Volchkov… - Annals of …, 2015 - Taylor & Francis
Human pluripotent stem cells (hPSCs) have practically unlimited proliferation potential and a
capability to differentiate into any cell type in the human body. Since the first derivation in …
capability to differentiate into any cell type in the human body. Since the first derivation in …
[PDF][PDF] Patient-specific pluripotent stem cells become even more accessible
S Yamanaka - Cell Stem Cell, 2010 - cell.com
In this issue of Cell Stem Cell, Staerk et al.(2010), Seki et al.(2010), and Loh et al.(2010)
each describe the derivation of human iPSCs from peripheral blood. Although seemingly …
each describe the derivation of human iPSCs from peripheral blood. Although seemingly …
Translation of human-induced pluripotent stem cells: from clinical trial in a dish to precision medicine
The prospect of changing the plasticity of terminally differentiated cells toward pluripotency
has completely altered the outlook for biomedical research. Human-induced pluripotent …
has completely altered the outlook for biomedical research. Human-induced pluripotent …