The nature of the primary genetic defects in ob/ob and db/db mice are unknown. Both the
obese (ob) and diabetes (db) mutations produce similar, multicomponent obese …

The nature of the genetic defects which define the obese (ob) and diabetes (db) loci in mice
remain unknown, but both produce similar syndromes when maintained in the same strain of …

A new congenic strain of obese mice, C57BK/KsJ-ob, has been developed for comparison
with the C57BL/6J-ob congenic strain. While obese mice of both strains are characterized by …

Hyperinsulinaemia is a consistent feature of obesity; studies on the hyperactivity of the β-cell
function of the endocrine pancreas in experimental and genetic obesity in rodents are …

Dynamic changes in VMH and PVN monoamines and immunoreactive insulin (IRI) were
investigated by microdialysis in freely‐moving genetically obese Zucker rats in order to …

In a previous publication from this laboratory [1] it was shown that perifusing the pituitaries of
lean and obese mice in series with isolated pancreatic islets produced a rapid stimulation of …

Blood glucose, plasma insulin and pancreatic insulin content in obese mice (obob) have
been measured at various ages and compared to results from normal mice. Plasma insulin …

We have recently shown that in addition to β-endorphin the opioid peptides Met-and Leu-
enkephalin and their apparent precursors are localized in islet endocrine cells of the rat …

The diabetes syndromes produced by the two single gene mutations, obese (ob), and
diabetes (db) are identical when both genes are expressed on the same inbred background …

Recent reports have suggested that the obesity and hyperphagia of the genetically obese
Zucker rat may be related to defective insulin action or binding in the hypothalamus. We …