Polo-like kinases (PLKs) are marked by C-terminal polo box modules with critical protein
interaction and subcellular targeting roles. Slevin et al. in this issue of Structure reveal the …

Abstract Polo-like kinase 2 (PLK2) is a crucial regulator in cell cycle progression, DNA
damage response, and neuronal activity. PLK2 is characterized by the conserved N-terminal …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

Polo-like kinases (Plks) perform crucial functions in cell-cycle progression and multiple
stages of mitosis. Plks are characterized by a C-terminal noncatalytic region containing two …

Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …

Polo-like kinases (Plks) contain a conserved Polo-box domain, shown to bind to
phosphorylated Ser-pSer/pThr-Pro motifs. The Polo-box domain of Plk-1 mediates substrate …

New work by Elia et al. in this issue of Cell reveals the molecular basis of phosphopeptide
recognition by the polo domain and the domain's dual function to promote substrate …

Polo-like kinases (PLKs) belong to the serine/threonine kinase subfamily, characterized by
the presence of the signature motif called Polo-box domain. PLK members studied so far …

Members of the polo subfamily of protein kinases have emerged as important regulators in
diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests …

Mammalian polo-like kinase 1 (Plk1) has been studied intensively as a key regulator of
various cell cycle events that are critical for proper M-phase progression. The polo-box …