Cumulative effect of obesity phenotypes on body weight and body mass index

W Ghusn, L Cifuentes, D Anazco, S Fansa… - International Journal of …, 2024 - nature.com
Background Obesity originates from an imbalance between energy intake and expenditure.
Changes in energy intake components (satiation, postprandial satiety, emotional eating) and …

Chronic medical conditions based obesity phenotypes: a two-step cluster analysis of a representative sample of obese American adults

IS Okosun, B Okosun, R Lyn, TL Henry - Diabetes & Metabolic Syndrome …, 2019 - Elsevier
Background and objective Although obesity is a heterogeneous disease, little is known
regarding chronic medical conditions (CMCs) that defines variability in obese populations …

[HTML][HTML] A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity

SJM Sag, S Mueller, S Wallner, C Strack, U Hubauer… - Medicine, 2023 - journals.lww.com
Genome wide association studies have identified numerous single nucleotide
polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small …

[HTML][HTML] Heterogeneous Comorbidity in Individuals With Different Phenotypes of Obesity

AR Nurieva, SD Parve, AV Sineglazova - Cureus, 2023 - ncbi.nlm.nih.gov
Materials and methods This case-control study was conducted at the Clinical and Diagnostic
Center of the Aviastroitelny District, Kazan. Patients were selected based on BMI per …

Combined analyses of 20 common obesity susceptibility variants

CH Sandholt, T Sparsø, N Grarup, A Albrechtsen… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Genome-wide association studies and linkage studies have identified 20
validated genetic variants associated with obesity and/or related phenotypes. The variants …

Identifying obesity subtypes: A review of studies utilising clinical biomarkers and genetic data

A Abraham, H Yaghootkar - Diabetic Medicine, 2023 - Wiley Online Library
Obesity is a complex and multifactorial condition that poses significant health risks. Recent
advancements in our understanding of obesity have highlighted the heterogeneity within this …

Distinct genetic subtypes of adiposity and glycemic changes in response to weight-loss diet intervention: the POUNDS Lost trial

Y Chen, T Zhou, D Sun, X Li, H Ma, Z Liang… - European journal of …, 2021 - Springer
Purpose Obesity is a heterogeneous condition and distinct adiposity subtypes may
differentially affect type 2 diabetes risk. We assessed relations between genetically …

Healthy obesity

RP Wildman - Current Opinion in Clinical Nutrition & Metabolic …, 2009 - journals.lww.com
A high prevalence of the healthy obese phenotype has been reported, and these individuals
appear to be at no increased risk of CVD. Further research is needed into the mechanisms …

Metabolic and body composition factors in subgroups of obesity: what do we know?

AD Karelis, DH St-Pierre, F Conus… - The Journal of …, 2004 - academic.oup.com
Obesity is thought to be a heterogeneous disorder with several possible etiologies;
therefore, by examining subtypes of obesity we attempt to understand obesity's …

How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank

M Zhang, J Ward, RJ Strawbridge, C Celis-Morales… - BMC medicine, 2024 - Springer
Background Obesity and central obesity are multifactorial conditions with genetic and non-
genetic (lifestyle and environmental) contributions. There is incomplete understanding of …