Membrane-associated oxidative stress has been implicated in the synaptic dysfunction and
neuronal degeneration that occurs in Alzheimer's disease (AD), but the underlying …

The plasma membrane (PM) contains redox enzymes that provide electrons for energy
metabolism and recycling of antioxidants such as coenzyme Q and α-tocopherol. Brain …

Reactive oxygen species (ROS) have important roles as signaling molecules in the
regulation of a variety of biological processes. On the other hand, chronic oxidative stress …

Mitochondria‐deficient cells (ρo cells) survive through enhanced glycolytic metabolism in
the presence of pyruvate and uridine. The plasma membrane redox system (PMRS) …

Alzheimer disease (AD) is a neurodegenerative disease with many known pathological
features, yet there is still much debate into the exact cause and mechanisms for progression …

Generation of reactive oxygen species (ROS) causes cellular oxidative damage and has
been implicated in the etiology of Alzheimer's disease (AD). In contrast, multiple lines of …

Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal
death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and …

Age-associated neurodegenerative disorders are becoming more prevalent as the mean
age of the population increases in the United States over the next few decades. Both normal …

Alzheimer's disease (AD) is a late‐onset dementia that is characterized by the loss of
memory and an impairment of multiple cognitive functions. Advancements in molecular …

Evidence for free radical damage in Alzheimer's disease includes damage to lipids, proteins,
and nucleic acids and is likely a consequence of redox-active metal accumulations …