Do biologic parameters affect the time to first treatment of clinical monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Rai stage 0? Results of a …

S Molica, D Giannarelli, L Levato, M Gentile… - … Myeloma and Leukemia, 2015 - Elsevier
Background We investigated the clinical relevance of classic and new prognostic markers,
immunoglobulin heavy-chain variable (IGHV) gene mutational status, and chromosomal …

Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: a comparison of cellular, cytogenetic, molecular, and clinical features

F Morabito, L Mosca, G Cutrona, L Agnelli, G Tuana… - Clinical cancer …, 2013 - AACR
Purpose: To investigate the incidence and clinical relevance of classic and new prognostic
markers, IGHV gene mutational status, and chromosomal abnormalities in clinical …

A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal …

S Molica, D Giannarelli, L Levato, R Mirabelli… - International journal of …, 2014 - Springer
We propose an algorithm based on a slightly modified version of MD Anderson Cancer
Center (MDACC) score (ie, mutational status of IgVH, LDH, presence of high-risk FISH …

The CLL International Prognostic Index predicts outcomes in monoclonal B-cell lymphocytosis and Rai 0 CLL

SA Parikh, KG Rabe, NE Kay, TG Call… - Blood, The Journal …, 2021 - ashpublications.org
The utility of the chronic lymphocytic leukemia-international prognostic index (CLL-IPI) in
predicting outcomes of individuals with Rai 0 stage CLL and monoclonal B-cell …

Prognostic and predictive effect of IGHV mutational status and load in chronic lymphocytic leukemia: focus on FCR and BR treatments

A Visentin, M Facco, C Gurrieri, E Pagnin… - … Myeloma and Leukemia, 2019 - Elsevier
Background Most important markers in chronic lymphocytic leukemia (CLL) are TP53
abnormalities, including mutations and deletions, and the mutational status of …

The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors

D Rossi, E Sozzi, A Puma, L De Paoli… - British journal of …, 2009 - Wiley Online Library
Monoclonal B‐cell lymphocytosis (MBL) is an asymptomatic monoclonal expansion of< 5· 0×
109/l circulating CLL‐phenotype B‐cells. The relationship between MBL and Rai 0 CLL, as …

Immunoglobulin heavy chain variable region gene (IGHV) and prediction of time to first treatment (TTFT) in patients with chronic lymphocytic leukemia (CLL) …

F Morabito, TD Shanafelt, M Gentile, G Reda… - American journal of …, 2018 - air.unimi.it
The mutation status of the immunoglobulin heavy chain variable region gene (IGHV) is a
well-recognized prognostic indicator in patients with chronic lymphocytic leukemia (CLL) …

Intensity of antigen expression reflects IGHV mutational status and Dohner-defined prognostic categories in chronic lymphocytic leukemia, monoclonal B-cell …

J Balakrishna, N Basumallik, R Matulonis… - Leukemia & …, 2021 - Taylor & Francis
We demonstrate the prognostic utility of antigen quantitation in chronic lymphocytic
leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis …

The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)–like monoclonal B lymphocytosis is different from CLL: diagnostic implications …

A Dagklis, C Fazi, C Sala, V Cantarelli… - Blood, The Journal …, 2009 - ashpublications.org
Abstract In the revised National Cancer Institute Working Group (NCI-WG)/International
Workshop on Chronic Lymphocytic Leukemia (IWCLL) guidelines for CLL, CLL-like …

Prospective study of prognostic factors in asymptomatic patients with B-cell chronic lymphocytic leukemia-like lymphocytosis: the cut-off of 11 × 109/L monoclonal …

AC Oliveira, A Fernandez de Sevilla, A Domingo… - Annals of …, 2015 - Springer
The arbitrary threshold of 5× 10 9/L chronic lymphocytic leukemia (CLL)-like lymphocytes
differentiates monoclonal B lymphocytosis (MBL) from CLL. There are no prospective …