Association of gastric mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment

M Nishino, M Sugimoto, T Uotani, M Yamade, S Sahara… - Digestion, 1957 - karger.com
Introduction: The antiplatelet effects of low-dose aspirin (LDA) vary between individuals.
Here, we investigated the relationship between the incidence of LDA-induced mucosal …

[HTML][HTML] Comparison of the degree of gastric mucosal injury between patients who are receiving dual antiplatelet therapy or single antiplatelet therapy

Y Shimada, M Hojo, Y Kita, Y Ikeda, S Sato, A Murata… - Diagnostics, 2022 - mdpi.com
Background: Patients taking low-dose aspirin have a higher incidence of gastroduodenal
ulcers and higher risk of upper gastrointestinal bleeding than patients who do not …

Adverse Effects of Low-Dose Aspirin in the Gastrointestinal Tract

K Iijima - NSAIDs and Aspirin: Recent Advances and …, 2016 - Springer
Low-dose aspirin (LDA) is now broadly administered for the prevention of cardiovascular
and cerebrovascular diseases. However, aspirin, even at a low dose, induces adverse …

[HTML][HTML] Small bowel injury in low-dose aspirin users

H Endo, E Sakai, T Kato, S Umezawa… - Journal of …, 2015 - Springer
The use of low-dose aspirin (LDA) is well known to be associated with an increased risk of
serious upper gastrointestinal complications, such as peptic ulceration and bleeding. Until …

A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel

K Tozawa, T Oshima, T Okugawa, T Ogawa… - Digestive diseases and …, 2014 - Springer
Introduction Antithrombotic drugs, such as low-dose aspirin (LDA) and clopidogrel, can
cause upper gastrointestinal complications. Aim The goal of the present study was to …

Impact of acid inhibition on esophageal mucosal injury induced by low-dose aspirin

M Sugimoto, M Nishino, C Kodaira, M Yamade… - Digestion, 1956 - karger.com
Abstract Background and Aim: Aspirin enjoys widespread use as an antithrombotic drug, but
such ubiquity also increases the risk of gastrointestinal mucosal injury. Recent studies have …

Antiplatelet drugs are a risk factor for esophageal mucosal injury

M Sugimoto, T Uotani, M Nishino, M Yamade, S Sahara… - Digestion, 2013 - karger.com
Background: In esophagus whether antiplatelet drugs, such as low-dose aspirin (LDA) and
clopidogrel, induce mucosal injury by pH changes or by acid reflux is unclear. We designed …

[HTML][HTML] Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy

J Iwamoto, Y Saito, A Honda… - World journal of …, 2013 - ncbi.nlm.nih.gov
Low-dose aspirin (LDA) is clinically used for the prevention of cardiovascular and
cerebrovascular events with the advent of an aging society. On the other hand, a very low …

Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans

B Cryer, M Feldman - Gastroenterology, 1999 - Elsevier
Background & Aims: The safety of low-dose daily aspirin therapy in the gastrointestinal tract
is uncertain. Our objectives were to evaluate the long-term effects of very low daily aspirin …

[HTML][HTML] Clinical use of low-dose aspirin for elders and sensitive subjects

Y Zhang, XM Fang, GX Chen - World Journal of Clinical Cases, 2019 - ncbi.nlm.nih.gov
The use of low-dose aspirin (LDA) has been a common preventive measure to reduce the
risk of cardiovascular events. This is attributed to aspirin's ability to inhibit platelet activation …