Selenium chemoprevention of liver cancer in animals and possible human applications

SY Yu, YJ Chu, WG Li - Selenium: Present Status and Perspectives in …, 1988 - Springer
An inverse correlation between geographic distribution of liver cancer incidence and the
selenium (Se) contents of whole blood and grains was observed in Qidong county, Jiangsu …

A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China

SY Yu, WG Li, QS Huang, C Zhi-Huang… - Biological trace element …, 1991 - Springer
The purpose of this study was to evaluate the effect of selenium (Se) in the prevention of
human primary liver cancer. Three intervention trials were conducted among the residents at …

The prevention of primary liver cancer by selenium in high risk populations

W Li, Y Zhu, X Yan, Q Zhang, X Li, Z Ni… - … yu fang yi xue za zhi …, 2000 - europepmc.org
Methods After screening of blood samples in 18,000 males from 20 to 65 years-old in
Qidong, Jiangsu province (a high risk area for liver cancer), 2,065 cases of HBsAg positive …

The effect of selenium on cell proliferation in liver and colon

MA Tempero, EE Deschner, MS Zedeck - Biological Trace Element …, 1986 - Springer
Epidemiologic and experimental evidence support a chemoprotective role for selenium (Se)
in malignancy. Many mechanisms have been proposed to explain this phenomenon. In this …

Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats

N Alwahaibi, J Mohamed, A Alhamadani - Journal of Trace Elements in …, 2010 - Elsevier
Selenium is an essential micronutrient mineral found mainly in soils and has been shown to
prevent certain cancers in humans and animals. However, the dose and effects of selenium …

Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong

S Yu Yu, YJ Zhu, WG Li - Biological trace element research, 1997 - Springer
High rates of hepatitis B virus (HBV) infection and primary liver cancer (PLC) are present in
Qidong county. Epidemiological surveys demonstrated an inverse association between …

Regional variation of cancer mortality incidence and its relation to selenium levels in China

SY Yu, YJ Chu, XL Gong, C Hou, WG Li… - Biological trace element …, 1985 - Springer
The epidemiological relationship between selenium level and age-adjusted human cancer
mortality (incidence) was studied in 24 regions located in eight provinces of China …

Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China

LC Sakoda, BI Graubard, AA Evans… - … journal of cancer, 2005 - Wiley Online Library
Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in
humans. However, few studies have examined the association between Se nutrient status …

Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats

JG Liu, HJ Zhao, YJ Liu, Y Liu, XL Wang - Journal of Trace Elements in …, 2012 - Elsevier
This experiment was designed to compare the effect of two selenium sources at the dosage
of therapeutic level on hepatocarcinogenesis and angiogenic cytokines in DEN-induced …

Effects of selenium supplementation on hepatocarcinogenesis in rats

TM Aquino, EA Porta, HM Sablan, RD Dorado - 1985 - Taylor & Francis
Four groups of weanling male Wistar rats (Groups A—D) received diethylnitrosamine (DEN,
40 ppm) in their drinking water for four weeks; after a recovery period of two weeks, they …