In rabbits the 3′-most VH gene (VH1) is predominantly rearranged, limiting combinatorial
diversity. In man and mouse, the 3′-most DH gene, DQ52, is preferentially rearranged early …

Rabbits predominantly rearrange the most 3′ VH gene (VH1); thus combinatorial diversity
is very limited. In man and mouse, the most 3′ DH gene, DQ52, is preferentially rearranged …

The neonatal antibody repertoire in both mouse and humans differs from that of the adult
repertoire in that the neonatal repertoire uses a limited set of JH-proximal VH genes but the …

In normal rabbits, 80% of the VHDHJH genes use the 3′-most VH gene segment, VH 1,
and the other 20% use VH gene segments about 50 kb 3′ of VH 1, VH x or VH y. In mutant …

The functional B cell repertoire in BALB/c mice was assessed at various stages in ontogeny.
This was done by analyzing VH gene family expression using the sensitive technique of in …

Polyclonal B cell leukemias have been generated in 17‐to 20‐day old Eμ‐myc transgenic
rabbits. To analyze the repertoire of VH genes utilized in early B cells, eight VDJ genes were …

Extrachromosomal circular DNA purified from bone marrow cells of 2‐weeks‐old rabbits was
assayed by polymerase chain reaction to determine the relative rearrangement frequencies …

Preferential usage of JH‐proximal VH genes has been demonstrated in immature murine B
cell repertoires. To determine whether this phenomenon is also evident in human …

We have previously demonstrated a dramatic preference for utilization of the most JH-
proximal VH gene segments in the newborn liver versus adult spleen. We now examine in …

During B lymphocyte development, Ig heavy and L chain genes are assembled by V (D) J
recombination. Individual V, D, and J genes rearrange at very different frequencies in vivo …