A series of optical amino acid diosgenyl esters and diosgenyl salicylate conjugates were
designed and synthesized to develop new anticancer and anti-inflammatory agents. The …

In this work, we evaluated the antiproliferative and anti-inflammatory activities of two
diosgenin prodrugs. The prodrugs were obtained by esterification of diosgenin at position 3 …

Developing novel anti-inflammatory drugs is increasingly important in modern
pharmaceutical industry. In this work, the reactions of both amino acids and their …

Thirty-two novel DG F-spiroacetal ring-opening derivatives, including 24 acetylated
derivatives and 8 nitrogenous derivatives, were designed and synthesized from diosgenin …

AbractDiosgenin (DG) is a natural steroidal compound with a variety of biological activities.
Studies have shown that the anti-inflammatory activity of DG is particularly prominent, which …

Esterification of glycyrrhetinic acid (GA) with dehydrozingerone (DZ) resulted in a novel
cytotoxic GA–DZ conjugate. Based on this exciting finding, we conjugated eleven different …

A new class of 2, 5-disubstituted-dioxacycloalkanes were designed and synthesized via
stereoselective synthetic method as cancer chemoprevention agents. The anti-inflammatory …

A series of novel conjugates with ursolic acid core and different chalcone ligands were
synthesized via ursolic acid, 4-hydroxyacetophenone and aromatic aldehydes. All of the …

In order to obtain better anti-cancer compounds, nine glycosylated derivatives were
designed and synthe-sized using diosgenin as starting material. Their structures were …