[HTML][HTML] Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas
Pathogen fitness landscapes change when transmission cycles establish in non-native
environments or spill over into new vectors and hosts. The introduction of Leishmania …
environments or spill over into new vectors and hosts. The introduction of Leishmania …
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and …
G Bussotti, E Gouzelou, M Côrtes Boité, I Kherachi… - MBio, 2018 - Am Soc Microbiol
Protozoan parasites of the genus Leishmania adapt to environmental change through
chromosome and gene copy number variations. Only little is known about external or …
chromosome and gene copy number variations. Only little is known about external or …
[HTML][HTML] Phylogenetic and biogeographical traits predict unrecognized hosts of zoonotic leishmaniasis
CK Glidden, AR Murran, RA Silva… - PLOS Neglected …, 2023 - journals.plos.org
The spatio-temporal distribution of leishmaniasis, a parasitic vector-borne zoonotic disease,
is significantly impacted by land-use change and climate warming in the Americas …
is significantly impacted by land-use change and climate warming in the Americas …
[HTML][HTML] Interspecies and Intrastrain Interplay among Leishmania spp. Parasites
BD das Chagas, TM Pereira, LM Cantanhêde… - Microorganisms, 2022 - mdpi.com
Leishmania parasites present astonishing adaptative abilities that represent a matter of life
or death within disparate environments during the heteroxenous parasite life cycle. From an …
or death within disparate environments during the heteroxenous parasite life cycle. From an …
[HTML][HTML] Colonization and genetic diversification processes of Leishmania infantum in the Americas
Leishmania infantum causes visceral leishmaniasis, a deadly vector-borne disease
introduced to the Americas during the colonial era. This non-native trypanosomatid parasite …
introduced to the Americas during the colonial era. This non-native trypanosomatid parasite …
[HTML][HTML] Experimental evolution links post-transcriptional regulation to Leishmania fitness gain
L Piel, KS Rajan, G Bussotti, H Varet… - PLoS …, 2022 - journals.plos.org
The protozoan parasite Leishmania donovani causes fatal human visceral leishmaniasis in
absence of treatment. Genome instability has been recognized as a driver in Leishmania …
absence of treatment. Genome instability has been recognized as a driver in Leishmania …
[HTML][HTML] Leishmania genome variability: Impacts on parasite evolution, parasitism and leishmaniases control
Leishmania are protozoan pathogens that cause leishmaniasis, a neglected disease with
debilitating and potentially life-threatening symptoms. The Leishmania genome is very …
debilitating and potentially life-threatening symptoms. The Leishmania genome is very …
Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani
P Prieto Barja, P Pescher, G Bussotti… - Nature ecology & …, 2017 - nature.com
The parasite Leishmania donovani causes a fatal disease termed visceral leishmaniasis.
The process through which the parasite adapts to environmental change remains largely …
The process through which the parasite adapts to environmental change remains largely …
Perspectives on Leishmania species and stage-specific adaptive mechanisms
A Subramanian, RR Sarkar - Trends in parasitology, 2018 - cell.com
The hurdles in drug and vaccine development pipelines for leishmaniasis, a complex,
multifaceted disease, are largely due to the digenetic lifecycle, differential clinical …
multifaceted disease, are largely due to the digenetic lifecycle, differential clinical …
[HTML][HTML] Parasite hybridization promotes spreading of endosymbiotic viruses
S Heeren, I Maes, M Sanders, LF Lye, J Arevalo… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Viruses are the most abundant biological entities on Earth and play a significant role in the
evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of …
evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of …